Model systems for understanding DNA base pairing
نویسندگان
چکیده
منابع مشابه
Molecular electrostatic potentials of DNA base-base pairing and mispairing.
An understanding of why adenine (A) pairs with thymine (T) and cytosine (C) with guanine (G) in DNA is very useful in the design of sensors and other related devices. We report the use of dissociation energies, geometries and molecular electrostatic potentials (MEPs) to justify the canonical (AT and CG) Watson-Crick pairs. We also analyze all mismatches in both configurations-cis and trans-with...
متن کاملSelective and Stable DNA Base Pairing without Hydrogen Bonds.
Noncovalent interactions between aromatic nucleobases are the major stabilizing forces which contribute to the structural integrity of duplex DNA and RNA.1-3 However, base pairing in nucleic acids is a consequence of more than just hydrogen bonding alone. The predictive success of nearest neighbor analysis,4 along with “dangling base” measurements which show duplex stabilization in the absence ...
متن کاملWatson-Crick base-pairing properties of tricyclo-DNA.
Tricyclo-DNA belongs to the family of conformationally restricted oligodeoxynucleotide analogues. It differs structurally from DNA by an additional ethylene bridge between the centers C(3') and C(5') of the nucleosides, to which a cyclopropane unit is fused for further enhancement of structural rigidity. The synthesis of the hitherto unknown tricyclodeoxynucleosides containing the bases cytosin...
متن کاملStatistical mechanics of base stacking and pairing in DNA melting.
We propose a statistical mechanics model for DNA melting in which base stacking and pairing are explicitly introduced as distinct degrees of freedom. Unlike previous approaches, this model describes thermal denaturation of DNA secondary structure in the whole experimentally accessible temperature range. Base pairing is described through a zipper model, base stacking through an Ising model. We p...
متن کاملStretching single-stranded DNA: interplay of electrostatic, base-pairing, and base-pair stacking interactions.
Recent single-macromolecule observations revealed that the force/extension characteristics of single-stranded DNA (ssDNA) are closely related to solution ionic concentration and DNA sequence composition. To understand this, we studied the elastic property of ssDNA through the Monte Carlo implementation of a modified freely jointed chain (FJC), with electrostatic, base-pairing, and base-pair sta...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2007
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2007.09.019